Table 3 –
4-Parameter Sigmoid Curve Baroreflex Components
| Heart Rate Baroreflex Response | |||||||
|---|---|---|---|---|---|---|---|
| TG Controls | ETB-def | ||||||
| Normal Salt (8) | High Salt (5) | Normal Salt (8) | High Salt (5) | 2-way ANOVA (p) | |||
| Bottom Plateau (ms) | 213.0 ± 7.5 | 213.5 ± 11.32 | 210.3 ± 8.0 | 191.3 ± 14.5 | S = 0.4028 | G = 0.2664 | S*G = 0.3746 |
| Top Plateau (ms) | 241.7 ± 10.3 | 239.2 ± 6.6 | 226.2 ± 13.3 | 204.5 ± 11.4 | S = 0.2799 | G = 0.0184 | S*G = 0.2145 |
| MAP BP50 (mmHg) | 140.6 ± 7.5 | 129.8 ± 9.6 | 146.1 ± 11.8 | 132.0 ± 13.72 | S = 0.7145 | G = 0.2514 | S*G = 0.3436 |
| Max Gain (ms / mmHg) | 0.99 ± 0.29 | 0.76 ± 0.21 | 0.42 ± 0.24 | −0.17 ± 0.38 | S = 0.1670 | G = 0.0167 | S*G = 0.5528 |
| Baseline IBI (ms) | 204.5 ± 9.4 | 235.2 ± 8.4 | 211.8 ± 9.3 | 197.2 ± 11.7 | S = 0.4273 | G = 0.1378 | S*G = 0.0327 |
| Baseline MAP (mmHg) | 101.1 ± 2.5 | 95.1 ± 3.1 | 96.5 ± 4.2 | 115.3 ± 3.8 | S = 0.0754 | G = 0.0348 | S*G = 0.0019 |
| RSNA Baroreflex Response | |||||||
| TG Controls | ETe-def | ||||||
| Normal Salt (8) | High Salt (5) | Normal Salt (8) | High Salt (5) | 2-way ANOVA (p) | |||
| Bottom Plateau (%) | 28.8 ± 9.3 | 37.22 ± 7.3 | 40.6 ± 6.9 | 51.3 ± 12.3 | S = 0.3097 | G = 0.1758 | S*G = 0.9008 |
| Top Plateau (%) | 122.5 ± 13.6 | 118.8 ± 7.8 | 109.9 ± 4.0 | 114.6 ± 8.2 | S = 0.9605 | G = 0.4363 | S*G = 0.7882 |
| MAP BP50 (mmHg) | 115.4 ± 3.8 | 99.4 ± 8.4 | 116.3 ± 5.0 | 120.2 ± 2.7 | S = 0.3540 | G = 0.1028 | S*G = 0.1345 |
| Max Gain (% / mmHg) | −3.8 ± 0.6 | −2.3 ± 0.4 | −1.4 ± 0.1G | −1.5 ± 0.1 | S = 0.1558 | G = 0.0022 | S*G = 0.0831 |
MAP: mean arterial pressure, IBI: inter beat interval, Normal salt (0.49% NaCl), High salt (4.0% NaCl), TG: transgenic controls; ETB-def: Endothelin B deficient; G: genotype, S: salt diet. 2-way ANOVA with Tukey’s post-hoc test for multiple comparisons:
G,
p < 0.05 genotype;
S,
p < 0.05 salt; Mean ± SEM.
Group effect significance indicated by italics.