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. Author manuscript; available in PMC: 2021 Apr 12.
Published in final edited form as: Nat Neurosci. 2011 Jan 30;14(3):279–284. doi: 10.1038/nn.2708

Figure 2.

Figure 2

Arc regulates neural circuit homeostasis. (a,b) Neuronal activity regulates Arc protein expression, which can act as a sensor for the amount of activity a neuron experiences in an epoch of time. Chronic changes in neuronal activity result in homeostatic processes that maintain a relative constant neuronal output. Many mechanisms have been implicated in these homeostatic changes; two important mechanisms are synaptic scaling of AMPARs (a) and modification of the LTP and LTD threshold (b). Arc has been shown to be critical for synaptic scaling of AMPARs but may also be involved in setting the threshold for LTP versus LTD. These processes are not mutually exclusive and may act in concert, depending on the precise activity patterns the neuron is subjected to. θm denotes modification threshold.