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. 2021 Mar 25;18(10):2228–2234. doi: 10.7150/ijms.56928

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The biomarkers to assess the prognosis. +: positive correlation; -: negative correlation; ?: no appropriate biomarkers in this work. Of male patients, in stage Ⅰ, there was a negative correlation between CD8 and prognosis, a positive correlation between CD4/CD8 and prognosis; in stage Ⅱ, a negative correlation between PLR and prognosis; in stage Ⅲ, a negative correlation between CD4/CD8 and prognosis; in stage Ⅳ, no appropriate biomarker was found. NLR/PLR was negatively correlated with prognosis in smoking stage Ⅰ female patients, while positively in no-smoking stage Ⅰ female patients. CD4/CD8 was negatively correlated with prognosis in smoking stage Ⅱ female patients, while positively in no-smoking stage Ⅳ female patients. There was a negative correlation between NLR and prognosis in smoking stage Ⅲ female patients; a positive correlation between CD8 and prognosis in no-smoking stage Ⅱ female patients. No appropriate biomarker was found in smoking stage Ⅳ and no-smoking stage Ⅲ female patients.