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. 2021 Mar 15;17(5):1178–1190. doi: 10.7150/ijbs.57783

Figure 5.

Figure 5

miR-31-5p partly reverses the cell proliferation caused by circMETTL3 in breast cancer cells lines. A-B. Cell proliferation of ZR-75-1 (A) and SUM1315 (B) cell lines transfected with negative control (si-NC), si-circMETTL3 (si-circ) or circMETTL3+miR-31-5p inhibitor (si-circMETTL3+inh) was determined by CCK-8. C: Cell proliferation of ZR-75-1 and SUM1315 cell lines transfected with negative control, si-circMETTL3 or circMETTL3+miR-31-5p inhibitor was determined by colony formation assay. Colonies > 50 mm were counted. D-E. Cell proliferation of ZR-75-1 (D) and SUM1315 (E) cell lines transfected with negative control, si-circMETTL3 or circMETTL3+miR-31-5p inhibitor. Blue indicates DAPI, red indicates EdU.Scale bar, 100 µm. Data were shown as mean ± SD, *p <0.05, **p <0.01, ***p<0.001.