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. 2021 Mar 15;17(5):1178–1190. doi: 10.7150/ijbs.57783

Figure 6.

Figure 6

miR-31-5p partly reverses the metastasis caused by circMETTL3 in breast cancer cells lines. A-C. The wound healing assays were used to detect the ZR-75-1(A) and SUM1315 (B) cell lines transfected with negative control (si-NC), si-circMETTL3 (si-circ) or circMETTL3+miR-31-5p inhibitor (si-circ+inh) migration ability. Scale bar, 100 µm D-G. Transwell assay was performed to determine the migration (D and F) and invasion (E and G) abilities of ZR-75-1 and SUM1315 cell lines transfected with negative control, si-circMETTL3 or circMETTL3+miR-31-5p inhibitor. Scale bar, 100 µm. Data were shown as mean ± SD, *p<0.01, **p <0.01, ***p<0.001.