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. 2021 Mar 15;17(5):1178–1190. doi: 10.7150/ijbs.57783

Figure 8.

Figure 8

circMETTL3 is upregulated in a m6A-dependent manner. A. Possibility of m6A modification of circMETTL3 B. Correlation between circMETTL3 and METTL3 expression in breast cancer tissues. C. Anti-m6A RIP experiments were performed to detect circMETTL3 expression. D. qRT-PCR showed METTL3 and circMETTL3 expression after knockdown of METTL3. E. qRT-PCR analysis of the transfection efficacy of siRNA on Mettl14 and FTO. F. qRT-PCR showed circMETTL3 and pre-METTL3 expression after knockdown of METTL14 or FTO. G. Schematic diagram illustrates the mechanism of circMETTL3 up-regulated in a m6A-dependent manner to promote breast cancer progression through circMETTL3/miR-31-5p/CDK1 axis. Data were shown as mean ± SD, *p <0.05, **p <0.01, ***p<0.001.