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. 2021 Mar 15;17(5):1191–1202. doi: 10.7150/ijbs.57871

Figure 3.

Figure 3

The function enrichment of PI3K/AKT and MAPK/ERK signaling pathways in the groups with different stemness scores levels. A. Heat map of correlation between stemness score and signaling molecules at transcriptional level. B. The GSEA showed the PI3K/AKT and MAPK signaling pathway enrichment results using TCGA-LUAD datasets. C-H. Biological process analysis of malignant characteristics of tumors in different groups. (C-D) Enriched results with correlation of PI3K/AKT/mTOR pathway in stemness scores high group (C) and low group (D), respectively. (E-F) Enriched results with correlation of MAPK/ERK pathway in stemness scores high group (E) and low group (F), respectively. (G-H) Enriched results with correlation of PI3K/AKT/mTOR combined MAPK/ERK pathway in stemness scores high group (G) and low group (H), respectively.