Table 3.
Different cargos released by exosomes regulate DIC
| Cargos | Classfications | Secreted cell and detailed cargo | Recipient cell | Effects | Ref. |
|---|---|---|---|---|---|
| DOX | NA | NA | Breast cancer cell | Increase DOX efficacy of killing tumors | 99 |
| Non-coding RNAs | miRNAs | Myeloid-derived suppressor cells (MDSC)-derived miR-126 | Tumor cell | Inhibition of exosomal miR-126 induce the death of MDSC | 106 |
| Monocytes-derived miR-159 | Breast cancer cell | Lead to cancer cell death | 107 | ||
| Adipose-MSC-derived miR-199a | Hepatocellular carcinoma (HCC) | Promote the death of HCC | 108 | ||
| Breast cancer tissue-derived miR-770 | Triple negative breast cancer (TNBC) | Induce the apoptosis of tumor cells | 109 | ||
| miR-501 | Gastric cancer(GC) | Inhibit the apoptosis of GC | 110 | ||
| lncRNAs | Breast cancer-derived lncRNA H19 | Breast cancer cell | Resist the apoptosis of cancer cells | 113 | |
| Mesenchymal stem cell (MSC)-derived lncRNA MALAT1 | Cardiomyocyte | Protect cardiomyocyte from senescence | 71 | ||
| Protein | CD47 | Tumor cell | Tumor cell | Anti-CD47enhances DOX-induced tumor death synergistically | 115 |