Fig. 2.

Variations in the levels of 48 cytokines in sera from immunized individuals. The levels of 48 cytokines in the sera of subjects who received the vaccine or the placebo were monitored. Subjects were assigned to the immunization procedure with an interval of 14 days (black) or with an interval of 28 days (blue). The measured cytokines included chemokines, interleukins (ILs), growth factors (GFs), colony-stimulating factors (CSFs), tumor necrosis factors (TNFs), and interferon (IFNs). The levels of 48 cytokines (pg/ml) in the sera of subjects before receiving the vaccine and placebo are shown as gray intervals between red dots in each figure. Control (Con, 0 EU); low dose (LD, 50 EU); medium dose (MD, 100 EU); and high dose (HD, 150 EU).