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. Author manuscript; available in PMC: 2021 Apr 12.
Published in final edited form as: J Thromb Haemost. 2018 Jun 21;16(7):1369–1382. doi: 10.1111/jth.14148

Table 1.

Overview of the study design for the combined tail vein transection (TVT)/rotational thromboelastometry (ROTEM) rat study

Group Rats Type of HA Rats per group for TVT (ROTEM) Treatment (dose, mg kg−1) Design
1 FVIII−/− Congenital 10 (5) Vehicle S
2 FVIII−/− Congenital 10 (5) TXA (350) S and B
3 FVIII−/− Congenital 10 (5) rFVIIa (0.5 ~ ED50) S and B
4 FVIII−/− Congenital 10 (5) rFVIIa (0.5 ~ ED50) + TXA (350) S and B
5 WT - 11 (5) Vehicle S

B, blinded; ED50, median effective dose; HA, hemophilia A; rFVIIa, activated recombinant factor VII; S, stratified; TXA, tranexamic acid; WT, wild type. All rats were subjected to the TVT bleeding assay. Following the TVT bleeding study, half of the rats had blood drawn from a carotid artery catheter for ROTEM analyses. Data from the study are shown in Figs 1 and 2.