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. 2021 Mar 30;118(14):e2026656118. doi: 10.1073/pnas.2026656118

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Fig. 8. — Cryo-EM structure of the B dENE construct without poly(A) at 8.7-Å resolution. (A and B) Density maps displayed at two contour levels (2.5σ, A; 3.5σ, B). The arrow indicates a hole in the lower dENE domain. (C) The dENE+poly(A) complex cryo-EM map with 8.7-Å resolution low-pass filtering, with poly(A) density subtracted (contoured at 3σ, salmon) and (D) its alignment with the free dENE map (contoured at 3.5σ, green). The two holes in C are in the upper and the lower URILs that form major-groove triple helices with poly(A). Upon poly(A) binding, local conformational changes occur in the lower dENE domain.