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. 2021 Apr 1;118(14):e1811725118. doi: 10.1073/pnas.1811725118

Fig. 2.

Fig. 2.

The 3D collagen-EV platform recapitulated microcalcifications seen in human atheroma. (A) SEM image of a microcalcification formed in the 3D collagen platform after 8 d of incubation with calcifying EVs. (B) Higher magnification view of yellow-outlined region in B. (C) DDC-SEM image of calcified atherosclerotic plaque from a human carotid endarterectomy sample. (D) Higher magnification SEM image of EVs aggregating in the 3D collagen platform. (E) TEM image of a microcalcification formed in the 3D collagen platform. (F) TEM image of calcified atherosclerotic plaque from human tissue sample.