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. 2021 Apr 1;118(14):e1811725118. doi: 10.1073/pnas.1811725118

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Copyright © 2021 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — BiP reduced the maximum size of calcific EV aggregates visualized via SEM. Changes in microcalcification size can be seen at low magnification (A vs. B) and high magnification (C vs. D). The average cross-sectional area of the five largest microcalcifications per high-powered field was significantly lower in the BiP-treated group versus the control group (E, n = 3 biological replicates). Elemental calcium and phosphorous composition of control and BiP-treated microcalcifications measured via EDS (F, nine technical replicates per group, n = 1 biological replicates, ***P < 0.001, ****P < 0.0001, error bars represent SD).