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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Acta Biomater. 2020 Apr 16;109:182–194. doi: 10.1016/j.actbio.2020.04.017

Figure 5: BMP2 EV mediated bone regeneration:

Figure 5:

A) Representative μCT images showing regeneration of bone in 5mm calvarial defects that were treated with plain collagen sponge (Control), collagen sponge containing control EVs (Ctrl. EV, 5x108 EVs per defect), collagen sponge containing BMP2 (BMP2 GF 5μg/defect) and collagen sponge containing BMP2 EV (5x108 EVs per defect) at 4, 8- and 12-weeks post wounding. The arrow in the 12-week BMP2 GF group shows ectopic bone formation. Scale bar represents 2.5mm. B) Volumetric quantitation of the μCT data expressed as percentage bone volume regenerated with mineralized tissue (n=6 defects per group per time point). * represents statistical significance with respect to the collagen control group (no EV) and # represents statistical significance with respect to the control EV group. The significance was calculated using Tukey’s ad-hoc test following one-way ANOVA.