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TNF-α regulates expression of transcription factors through NF-κB pathway. (A) TPC-1 and (B) BCPAP were pretreated with H-89 (50 μM), LY294002 (20 μM), BAY11-7082 (50 nM), JAK inhibitor 1 (5 μM) for 30 min and followed by stimulation wih TNF-α (20 ng/mL) for 36 h. The expression of Snail, Slug, Twist1, Zeb1, Zeb2 were examined by western blotting, expression of β-action serves as a loading contro.The results are representative of at least three independent experiments.
