Table 2.
The sensitivities, specificities and Youden indices of mSFRP2, mSDC2 and SpecColon test for detecting AA and CRC by different cut-off values in the training cohort
| mSFRP2 (%) | mSDC2 (%) | SpecColon (%) | ||
|---|---|---|---|---|
| Cut-off-1 | Sensitivity for AA (95% CI) | 53.8 (26.1-79.6) | 46.2 (20.4-73.9) | 61.5 (32.3-84.9) |
| Sensitivity for CRC (95% CI) | 84.7 (76.3-90.6) | 74.8 (65.5-82.3) | 89.2 (81.5-94.0) | |
| Specificity (95% CI) | 87.0 (79.4 - 92.2) | 98.4 (93.7-99.7) | 87.0 (79.4-92.2) | |
| Youden index for AA | 40.8 | 44.6 | 48.5 | |
| Youden index for CRC | 71.7 | 73.2 | 76.2 | |
| Cut-off-2 | Sensitivity for AA (95% CI) | 30.7 (10.3-61.1) | 46.2 (20.4-73.9) | 53.8 (26.1-79.6) |
| Sensitivity for CRC (95% CI) | 71.2 (61.7-79.2) | 74.8 (65.5-82.3) | 83.8 (75.3-89.9) | |
| Specificity (95% CI) | 94.3 (88.2-97.5) | 98.4 (93.7-99.7) | 93.5 (87.2-96.9) | |
| Youden index for AA | 25.0 | 44.6 | 51.8 | |
| Youden index for CRC | 66.4 | 73.2 | 76.8 | |