Figure 3.

Diverse cytogenetic mechanisms resulting in CBFA2T3–GLIS2 gene fusions. (A) Representative cytogenetic and FISH images used to identify Chromosome 16 abnormalities in patients 2, 4, and 5. See Table 3 for complete nomenclature. Cytogenetic studies are not available for patient 3. (B) Representative screenshot from the Archer software demonstrating a CBFA2T3–GLIS2 gene fusion between exons 11 and 3 of CBFA2T3 and GLIS2, respectively (i.e., C11G3). The same breakpoint was observed in all four patients.