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. 2021 Mar 30;118(14):e2100225118. doi: 10.1073/pnas.2100225118

Fig. 4.

Fig. 4.

Transcriptome analysis of STING-regulated genes in primary cells from STING mutant mice. (A) Heatmap showing the top 20 genes up-regulated in DMXAA-treated STING-S365A BMDMs relative to untreated WT cells. RNA was extracted from BMDMs treated with 75 μM DMXAA for 2 h. (B–D) qRT-PCR analysis of BMDCs treated with 75 μM DMXAA for 2 h. As baseline expression levels were comparable among untreated STING mutant cells, expression levels were normalized by untreated WT cells. (B) IFNα and IFNβ. (C) Interferon-stimulated genes. (D) Genes expressed highly in STING-S365A BMDCs. Error bars represent SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. mRNA, messenger RNA.