Table 1.
Patient demographics and clinical profiles in the training and validation cohort
| Demographics | Training Cohort | P-value | Validation Cohort | P-value | ||
|---|---|---|---|---|---|---|
| Case group | Control group | Case group | Control group | |||
| Overall number | 180 | 360 | / | 135 | 289 | / |
| Age, year (mean±SD) (Range) | 62.5±10.2 (33-84) | 60.7±8.9 (45-88) | 0.052 | 62.2±10.8 (27-83) | 58.0±7.7 (27-86) | <0.001 |
| Sex, No. of patients (%) | ||||||
| Male | 111 (61.7) | 218 (60.6) | 0.803 | 90 (66.7) | 180 (62.3) | 0.382 |
| Female | 69 (38.3) | 142 (39.4) | 45 (33.3) | 109 (37.7) | ||
| Nodule size, cm (mean±SD) | 2.3±2.0 a | 0.4±0.2 b | <0.001 | 2.6±2.3c | 0.4±0.2d | <0.001 |
| Smoking status, No. of patients (%) | ||||||
| Never | 112 (62.2) | 233 (64.7) | <0.001 | 83 (61.5) | 195 (67.5) | <0.001 |
| Current | 36 (20.0) | 58 (16.1) | 34 (25.2) | 44 (15.2) | ||
| Former | 30 (16.7) | 17 (4.7) | 18 (13.3) | 10 (3.5) | ||
| NA | 2 (1.1) | 52 (14.4) | 0 | 40 (13.8) | ||
| Stage, No. of patients (%) | ||||||
| I & II | 83 (46.1) | / | / | 55 (40.5) | / | / |
| III & IV | 85 (47.2) | 69 (51.1) | ||||
| NA | 12 (6.7) | 11 (8.2 | ||||
| Histological subtype, No. of patients (%) | ||||||
| SCLC | 15 (8.3) | 17 (12.6) | ||||
| NSCLC | 158 (87.8) | 112 (83.0) | ||||
| Not specified | 7 (3.9) | 6 (4.4) | ||||
Abbreviations: NA, not available; SCLC, small cell lung cancer; NSCLC, non-small cell lung cancer, including lung adenocarcinoma, lung squamous cell carcinoma, and large cell lung cancer.
Statistical analysis was performed using the unpaired two-tail Student t-test (for age and nodule size) and chi-square test (for sex and smoking status).
a: Data on nodule size was not available for 55 lung cancer cases.
b; Data on nodule size was not available for 272 controls.
c: Data on nodule size was not available for 42 lung cancer cases.
d: Data on nodule size was not available for 218 controls.