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. 2021 Mar 19;12(10):3011–3023. doi: 10.7150/jca.49707

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Effect of high expression of CXCL12 in Cancer-associated fibroblasts on survival of gastric cancer patients. Kaplan-Meier curves showing the impact of CXCL12^CAF and overall survival (OS) in 285 gastric cancer (GC) patients, P=0.0107. (B) Kaplan-Meier curves showing the impact of Wnt5a on the OS of patients, P=0.0063. (C) ROC curve showing the performance of the multivariate regression prediction model on patient prognosis, AUC = 0.749. (D) Kaplan-Meier curves showing the impact of CXCL12 on the OS of patients in TCGA-STAD dataset by TIMER tools, P = 0.066. (E) Kaplan-Meier curves showing the impact of CXCR4 on the OS of patients in the TCGA-STAD dataset by TIMER tools, P = 0.001. (F) Schematic diagram of CAFs affecting the progression of GC cells by secreting CXCL12.