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Plasma Protein Binding at 10 μM in Three Species, Expressed as Unbound Percenta
| compound | human, % freeb | mouse, % freeb | rat, % free |
|---|---|---|---|
| 12 | 0.48 | 0.29 | 0.00 |
| 21 | 1.13 | 0.94 | 0.00 |
| 23 | 0.00 | 0.83 | 0.00 |
| 25 | 1.25 | 1.33 | 0.00 |
Procedure is in the Supporting Information. Verapamil and warfarin served as positive controls.
Mean ± SD.
