Figure 3.

The group of human CMGC kinases. Of the 518 human protein kinases, 61 belong to the CMGC group and can be clustered into eight families and several sub-families of increasing sequence similarity and biochemical function. The unrooted kinase dendrogram shows the sequence similarity between the catalytic domains of the CMGC kinases: the distance along the branches between two kinases is proportional to the divergence between their sequences. Arrows indicate the kinases in SR proteins phosphorylation. NCBI accession number are indicated in gray. Illustration reproduced courtesy of Cell Signaling Technology, Inc. (www.cellsignal.com).