Table 1:
Demographic, neuropsychological, and MR imaging findings of study participants
| Study Participant Characteristic | AD (n = 77) | Healthy Control Participants (n = 77) | P Valueb |
|---|---|---|---|
| No. female (%) | 47 (61) | 44 (57) | .62 |
| Age, years,a | 72 (8) | 72 (8) | .98 |
| Age range, years | 51–87 | 51–87 | |
| MMSEa | 22.03 (3.72) | 27.57 (1.75) | <.001 |
| Global cortex volume, cm3a | 329.63 (14.53) | 394.04 (41.25) | <.001 |
| AD-signature regions volume, cm3a | 54.81 (10.15) | 70.28 (8.86) | <.001 |
| Global NAWM volume, cm3a | 305.77 (63.71) | 334.70 (52.52) | .01 |
| WM hyperintensities volume, cm3a | 16.19 (17.69) | 11.64 (18.01) | .02 |
| Fazekas grade 2 or 3, no. (%) | 49 (63.7) | 31 (40.3) | |
| Global cortex MTRsa | 0.295 (0.016) | 0.309 (0.008) | <.001 |
| AD-signature regions MTRsa | 0.297 (0.018) | 0.309 (0.009) | <.001 |
| Global NAWM MTRsa | 0.384 (0.009) | 0.388 (0.009) | .003 |
| WM hyperintensities MTRsa | 0.322 (0.028) | 0.350 (0.016) | <.001 |
a
Data are mean ± SDs.
b
Pearson χ2 for nominal, Wilcoxon, and paired t test for continuous variables were applied.