FIG 3.

A 63-year-old male patient with a history of diabetes, hypertension, chronic kidney disease, and obstructive sleep apnea admitted with COVID-19–related hypoxic respiratory failure due to acute respiratory distress syndrome. DWI (A–C) shows bilateral areas of reduced diffusivity, involving the body of the corpus callosum, middle cerebellar peduncles, and periventricular white matter (arrows, ADC not shown). Magnified axial T2-weighted MR images (D and E) show a peculiar cavitary appearance of some of the lesions, with decreased signal centrally and a peripheral T2-hyperintense rim (yellow arrows). These lesions were interpreted as areas of early cavitation within the white matter abnormalities. A follow-up MR imaging (not shown) showed resolution of the restricted diffusion within these lesions but with progression of the cavitary/necrotic changes.