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. 2021 Mar 19;144(3):800–816. doi: 10.1093/brain/awaa447

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Published by Oxford University Press on behalf of the Guarantors of Brain 2021. This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Multidimensional and voxel-averaged MRIs of TAI. (A–C) Control brain (Case 10). (A) APP histological images co-registered to MRIs. Deconvolved histological image: red = APP stain. Negligible APP density was detected. (B) Conventional MRI maps of T₁, T₂, FA and MD do not show visible abnormalities. (C) Multidimensional injury maps overlaid onto proton density images show absent of significant injury. (D–F) Non-fatal TBI brain (Case 6). (D) APP histological images co-registered to MRIs show visible TAI lesions in the corpus callosum. (E) Conventional MRI maps of T₁, T₂, FA and MD do not show visible abnormalities in the corpus callosum. (F) Multidimensional injury maps overlaid onto proton density images show significant injury in white matter (in particular, the T₁-T₂ injury SC). (G–I) Fatal TBI brain (Case 2). (G) APP histological images co-registered to MRIs show TAI lesions in regions of white matter/grey matter interface (white arrows). (H) Conventional MRI maps of T₁, T₂, FA and MD do not show visible abnormalities in white matter/grey matter interface. (I) Multidimensional injury maps overlaid onto proton density images show substantial injury along the white matter/grey matter interface.