Table 2.
Comparisons of MRI parameters and pathological measures among mild TAI, severe TAI, NAWM in mild and severe TAI tissue regions
| Variable |
NAWM in mTAI
n = 12 |
mTAI lesions
n = 12 |
NAWM in sTAI
n = 20 |
sTAI lesions
n = 20 |
mTAI lesions versus NAWM in mTAI |
sTAI lesions versus NAWM in sTAI |
sTAI lesions versus mTAI lesions |
|||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SE) | Mean (SE) | Mean (SE) | Mean (SE) | Estimated mean difference (95% CI) | P/PFDR |
Estimated mean difference
(95% CI) |
P/PFDR |
Estimated mean difference
(95% CI) |
P/PFDR | |
| T1-T2 SC, ×100 | 1.09 (0.39) | 4.09 (0.97) | 0.67 (0.29) | 4.70 (1.03) | 3.00 (0.95, 5.05) | <0.001/0.003 | 4.03 (1.93, 6.13) | <0.001/<0.001 | 0.74 (1.93, 3.41) | 0.667/0.943 |
| MD-T1 SC, ×100 | 0.56 (0.29) | 0.41 (0.20) | 0.46 (0.19) | 2.20 (0.64) | −0.15 (−0.84, 0.54) | 0.707/0.793 | 1.74 (0.43, 3.05) | 0.018/0.036 | 1.57 (0.24, 2.90) | 0.008/0.060 |
| MD-T2 SC, ×100 | 0.22 (0.24) | 1.14 (0.24) | 0.19 (0.19) | 2.84 (0.65) | 0.92 (0.25, 1.58) | 0.008/0.022 | 2.65 (1.32, 3.98) | <0.001/<0.001 | 1.72 (0.36, 3.08) | 0.015/0.060 |
| Adjusted FA | 1.00 (0.07) | 0.94 (0.23) | 1.00 (0.05) | 0.96 (0.15) | −0.06 (−0.54, 0.41) | 0.793/0.793 | −0.04 (−0.36, 0.28) | 0.790/0.790 | 0.02 (−0.53, 0.57) | 0.943/0.943 |
| Adjusted MD | 1.00 (0.06) | 1.04 (0.06) | 1.00 (0.05) | 1.13 (0.11) | 0.04 (−0.13, 0.21) | 0.675/0.793 | 0.13 (−0.09, 0.36) | 0.261/0.418 | −0.09 (−0.14, 0.33) | 0.452/0.903 |
| Adjusted T1 | 1.00 (0.03) | 0.97 (0.03) | 1.00 (0.02) | 0.95 (0.06) | −0.03 (−0.11, 0.05) | 0.504/0.793 | −0.04 (−0.17, 0.09) | 0.523/0.597 | −0.01 (−0.15 0.12) | 0.847/0.943 |
| Adjusted T2 | 1.00 (0.04) | 0.91 (0.04) | 1.00 (0.03) | 0.94 (0.08) | −0.09 (−0.20, 0.02) | 0.126/0.251 | −0.06 (−0.23, 0.11) | 0.497/0.597 | 0.03 (−0.15, 0.21) | 0.730/0.943 |
| % area APP | 0.40 (1.99) | 20.67 (3.71) | 0.97 (1.54) | 26.65 (6.35) | 20.27 (12.02, 28.52) | <0.001/<0.001 | 25.68 (12.87, 38.49) | <0.001/<0.001 | 5.96 (−8.45, 20.37) | 0.419/0.903 |
Values in bold indicate statistical significance. CI = confidence interval; mTAI = mild TAI; NAWM = normal-appearing white matter; SE = standard error; sTAI = severe TAI.