Figure 1.

Early neurotoxic stress depends on full-length and Δtau co-expression and is reversible. (A) P301S heterozygous mice (P301Shet; n = 5) at 21 days of age show no signs of paralysis upon tail suspension, and histological tests with AT8 antibody did not detect hyperphosphorylated tau or Gallyas-positive tau fibrils in the tegmental reticular nucleus. (B) Hindlimbs of P301SxTAU62^on mice (n = 5) the same age as their heterozygous littermates are paralysed; upon histological characterization, paralysed P301SxTAU62^on mice show hyperphosphorylated tau but no Gallyas-positive tau fibrils in the same region. (C) At 3 weeks after halting doxycycline administration, P301SxTAU62^on-off mice (n = 5) show recovered motor functions and reverted tau hyperphosphorylation. Scale bar = 75 µm (A–C).