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. 2021 Jan 23;144(3):963–974. doi: 10.1093/brain/awaa445

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Total tau levels in young P301SxTAU62^on-off mice do not decrease compared to their heterozygous littermates. Western blot analysis (HT7; A) and HT7/GAPDH ratio (B) for both P301Shet (n = 6) and P301SxTAU62^on-off (abbreviated P62^on-off) mice (n = 6). Tau levels were not significantly different between the two groups (P = 0.35). n.s. = P > 0.05. Box plots with hinges, whiskers and outliers. See also Supplementary Table 2.