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Seeding with high molecular weight tau results in the absence of fibrils in ALZ17 mice. ALZ17 mice seeded with brainstem (BS) homogenates from paralysed P301S homozygous (P301Shomo) mice (n = 5) revealed distinct granular tau pathology in CA1 (A) and the fornix (B), which was not detected in ALZ17 mice seeded with P301SxTAU62on brainstem homogenate (n = 4). Scale bar = 37.5 µm (A and B).
