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. 2021 Mar 29;9:641836. doi: 10.3389/fcell.2021.641836

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Copyright © 2021 Hua, Zhang, Sheng, Ning, Li, Shi and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Downregulation of NUCB1 was associated with poor prognosis in PDAC patients. (A–D) The association between gene expression patterns and survival rates of patients with PDAC was analyzed using the UALCAN database (annotated as PAAD dataset) (http://ualcan.path.uab.edu/analysis.html). Four members of the GEF family (CCDC88A, CCDC88C, NUCB1, and NUCB2) were examined. (E) Quantitative PCR was used to detect NUCB1 expression in 25 pairs of pancreatic cancer and adjacent tissues. (F) Immunohistochemistry (IHC) was used to examine NUCB1 protein expression in tissues. Scale bar: 100 μm. (G,H) Patients were divided into two groups based on IHC staining for survival curve analysis (G) and multivariate regression analysis (H).