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NUCB1 overexpression enhanced the anti-tumor effects of GEM in vivo. SW1990 cells with NUCB1 overexpression or control vector were subcutaneously injected into nude mice (n = 5 per group), and GEM (50 mg/kg) or vehicle was injected intraperitoneally. Xenograft growth curves (A) and tumor weights (B,C) were determined after 24 days. TUNEL staining (D) was conducted to detect apoptosis in xenografts. Scale bar: 50 μm. *p < 0.05, ***p < 0.01, ***p < 0.001.
