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ATF6 reversed the effects of NUCB1. SW1990 cells simultaneously overexpressing ATF6-pATF6 (active) and NUCB1 were treated with 20 μM GEM. Western blot (A,B) was conducted to determine protein levels of GRP78, CHOP, p90ATF6, p50ATF (active), NUCB1, p62, LC3-II/-I, and XBP-1. Immunofluorescence staining (C) was performed to detect LC3 expression. Scale bar: 50 μm. *p < 0.05, **p < 0.01.
