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(1) VPAHPND bacteria enter the shrimp and release PirABvp toxin. (2) The binary VPAHPND toxins bind to LvAPN1 receptor which is embeded in cell membrane of shrimp hemocyte. (3) This interaction might induce VPAHPND toxins oligomerization. (4) VPAHPND toxins induce pore formation and insert into membrane. (5) Hemocyte is lyzed and damaged causing by pore formation and membrane insertion.
