Table 1. In vitro dissolution data of 1 mg larazotide acetate of a delayed release formulation in 6 capsules.

	Sampling time points (minutes)	Time in GIT (minutes)	Average (±SD) Dissolution (%) of 1 mg LA (n = 6)
Simulated gastric media (Stomach)	0	0	0
	30	30	0
	60	60	0.1 ± 300
	120	120	0.7 ± 85.7
Simulated intestinal media (Small intestine)	15	135	1.4 ± 42.9
	30	150	39.7 ± 11.4
	45	165	41.2 ± 14.4
	60	180	42.8 ± 12.6
	90	210	79.1 ± 18.3
	120	240	93.7 ± 2.4
	180	300	93.7 ± 2.5

Times (minutes) in small intestine were back calculated by adding 120 minutes to sampling time point respectively. LA: larazotide acetate, GIT: gastrointestinal tract, SD: standard deviation