Table 2. Concentration data of larazotide acetate in the intestinal samples upon oral administration of 1mg larazotide acetate in a delayed release formulation in pigs.

Time (hour)	Probe Location	Average (±SD) Concentration of LA (μM) in intestinal fluid (n = 3)	Average (±SD) Volume (mL) of intestinal fluid (n = 3)
Clinical formulation	Distal duodenum
0		0.00 ± 0.00	2583 ± 93
1		0.74 ± 0.30	604 ± 259
2		0.27 ± 0.14	835 ± 72
3		0.12 ± 0.09	515 ± 75
4		0.03 ± 0.01	487 ± 113
	Proximal jejunum
0		0.00 ± 0.00	2364 ± 621
1		1.10 ± 0.48	720 ± 70
2		0.25 ± 0.13	575 ± 80
3		0.09 ± 0.10	765 ± 190
4		0.03 ± 0.04	556 ± 250
Placebo control	Distal duodenum
0		0.00 ± 0.00	1848 ± 929
1		0.00 ± 0.00	827 ± 113
	Proximal jejunum
0		0.00 ± 0.00	1751 ± 373
1		0.00 ± 0.00	943 ± 148

1μM of larazotide acetate (LA) = 0.71 μg/ml, SD: standard deviation