Fig 1. Regulatory network of the coupled immune system and circadian clock.

Schematic diagram of the acute immune response model (orange shapes) and the circadian clock (blue shapes) in the lung of a rat. In the circadian clock model, slanted boxes denote mRNAs; blue rectangles denote proteins; ovals denote protein complexes. Dotted arrows represent transactivation; blunt dashed arrows represent inhibition. In the acute inflammation model, P denotes endotoxin; D, damage marker; N, activated phagocytic cells; C_A, slow-acting anti-inflammatory cytokines.