Figure 1:
Model for mRNA decay on nonoptimal mRNA. The N-terminus of Not5 recognizes an empty E site on a slowly elongating ribosome. By recruiting CCR4-NOT, Not5 signals canonical Xrn1-mediated mRNA decay.
Model for mRNA decay on nonoptimal mRNA. The N-terminus of Not5 recognizes an empty E site on a slowly elongating ribosome. By recruiting CCR4-NOT, Not5 signals canonical Xrn1-mediated mRNA decay.