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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Mol Cell. 2021 Mar 12;81(7):1372–1383. doi: 10.1016/j.molcel.2021.02.022

Figure 2:

Figure 2:

Model for QC on internal ORF-stalled ribosomes. Ribosome collisions signal Hel2-dependent ubiquitination, Syh1-mediated mRNA decay through Xrn1, and both ribosome rescue by RQT (A) and endonucleolytic cleavage by Cue2 followed by Dom34:Hbs1 ribosome rescue (B).