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. Author manuscript; available in PMC: 2021 Apr 12.
Published in final edited form as: J Immunol. 2019 Nov 18;203(12):3237–3246. doi: 10.4049/jimmunol.1900245

Figure 6: Mice with Nrp1 deficient CD4 T cells have reduced atherosclerosis.

Figure 6:

Nrpfl/fl/LCkCre−/ApoE−/− (Cre−; Nrp+) and Nrpfl/fl/LCkCre+/ApoE−/− (Cre+; Nrp−) were fed a WD for 15 weeks. (A) Flow cytometry plots and bar graphs showing the percentages of Nrp1+Foxp3+ and Nrp1+Foxp3− CD4 T cells in the above mice in the PaLN and Aorta. (B) Images and bar graphs of enface Oil red O staining showing the level of atherosclerosis in the above mice. (C-E) Flow cytometry plots and/or bar graphs showing the percentages of naïve, effector memory CD4 T cells and Treg cells (C), IFNγ (D), and IL-17 production (E) in Aorta (C) and PaLN (D-E) of the above mice. Results are expressed as the mean ± s.e.m from two independent experiments (n=5-8 (A, C-E) and n=10 (B)). Statistically significant differences were at * P < 0.05, ** P < 0.01, and *** P < 0.001. NS = no significant differences.