Scheme 1. Synthesis of Final Compounds 3–12.
Reagents and conditions: (i) BnBr, EtOH, 75 °C, 5 h; (ii) Boc2O, DMAP, tetraethylammonium, CH2Cl2, rt, 0.5 h; (iii) sec-BuLi, TMEDA, THF, −78 °C, 6 h; (iv) FmocCl, MeCN, 90 °C, 5 h; (v) DBU, THF, rt, 2 h.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.