Figure 4.
Induction of AHR-driven genes in homozygous high-affinity conditional mutant (AhrV375A) compared with mice homozygous for the low-affinity conditional allele (Ahrfx) and homozygous wild-type animals (Ahrb1). Mice are treated with βNF or corn oil vehicle control (CO) for 4 h. Liver mRNA expression of AHR-driven genes relative to Hprt. Groups sharing a superscript are not different at the level of statistical significance (p > .05) determined by a 2-way ANOVA with multiple comparisons of the means (Tukey’s multiple comparison test). Each point represents the mean of 3 technical replicates of one biological replicate. Males are represented by a circle whereas females are represented by a square. Error bars represent standard error of the mean.