Figure 5.
Induction of AHR-driven genes in homozygous ligand-binding mutant (AhrNG367R) compared with mice homozygous for the high-affinity conditional allele (AhrV375A). Mice are treated with βNF or corn oil vehicle control (CO) for 4 h. Liver mRNA expression of AHR-driven genes relative to Hprt. Groups sharing a superscript are not different at the level of statistical significance (p > .05) determined by a 2-way ANOVA with multiple comparisons of the means (Tukey’s multiple comparison test). Each point represents the mean of 3 technical replicates of 1 biological replicate. Males are represented by a circle while females are represented by a square. Error bars represent standard error of the mean.