Table 1.

Nomenclature for Ahr Alleles

Mouse Strain	Formal Name	Informal Name	Technology	Description
Wild-type	C57BL/6J	Ahrb1	n/a	Wild-type allele found in B6 mice
Conditional	Ahrtm3.1Bra	Ahrfx	Homologous recombination	Low-affinity conditional allele; generated from 129 Sv ESCs (Ahrd at the Ahr locus)
Null	Ahr.tm1Bra	Ahr−/−	Homologous recombination	Exon 2 removed; generated from 129 Sv ESCs cells (Ahrd at the Ahr locus)
High affinity conditional	Ahrem1Bra	AhrV375A	CRISPR-Cas9	High-affinity conditional allele; Ahrd at the Ahr locus except for a single-nucleotide polymorphism at residue 375 introduced via homology directed repair
AhrNG367R	Ahrem2Bra	AhrNG367R	CRISPR-Cas9	Three-base pair deletion near ligand-binding domain generated through nonhomologous end joining; conditional; Ahrd at the Ahr locus
AhrTer383	Ahrem3Bra	AhrTer383	CRISPR-Cas9	Single-nucleotide insertion generated through nonhomologous end joining;Ahrd at the Ahr locus except for a fame shift at residue 371 resulting in 11 amino acid changes and early termination at residue 383; conditional

Mouse strain refers to the name commonly used in manuscripts and scientific presentations. The formal locus names listed are defined by the International Committee on Standardized Genetic Nomenclature for Mice and assigned by Jackson Laboratory. The informal locus names of alleles defines the name used in this article. The technology column describes the technique used to generate each model, followed by a brief description of important allelic traits.