Table 2.
Comparison of Bisphenol Cytotoxicity in C18-4, MA-10, and KGN Cells Using Benchmark Concentration (BMC) Analyses and Administered Equivalent Doses (AED) Estimation
| Chemical | Cell Line | BMR = 10%(BMC; BMCL; BMCU) | AED(AED; AEDL; AEDU) |
|---|---|---|---|
| BPA | C18-4 | 49.3 (38.3–66.2) | 3.6 (2.8–4.8) |
| MA-10 | 32.3 (22.8–44.3) | 2.3 (1.7–3.2) | |
| KGN | 70.8 (59.7–92.8) | 5.2 (4.3–6.7) | |
| BPAF | C18-4 | 17.0 (11.8–25.7) | 3.0 (2.1–4.6) |
| MA-10 | 13.5 (9.1–19.3) | 2.4 (1.6–3.5) | |
| KGN | 38.1 (31.7–44.4) | 6.8 (5.7–8.0) | |
| BPF | C18-4 | N/A (not cytotoxic) | N/A (not cytotoxic) |
| MA-10 | 46.3 (33.8- 62.8) | 4.0 (2.9–5.4) | |
| KGN | N/A (not cytotoxic) | N/A (not cytotoxic) | |
| BPS | C18-4 | N/A (not cytotoxic) | N/A (not cytotoxic) |
| MA-10 | 37.7 (27.0–50.8) | 0.3 (0.21–0.40) | |
| KGN | N/A (not cytotoxic) | N/A (not cytotoxic) | |
| BPM | C18-4 | 16.2 (11.7–24.3) | 3.8 (2.7–5.7) |
| MA-10 | 7.1 (5.1–9.7) | 1.7 (1.2–2.3) | |
| KGN | 22.7 (19.4–26.3) | 5.3 (4.5–6.2) | |
| BPTMC | C18-4 | 7.9 (5.6–11.5) | 0.4 (0.3–0.7) |
| MA-10 | 4.5 (2.9–6.7) | 0.3 (0.2–0.4) | |
| KGN | 14.7 (11.9–18.1) | 0.8 (0.7–1.0) |
BMCL, benchmark concentration lower limit; BMCU, benchmark concentration upper limit; Benchmark concentrations are μM. AEDL, administered equivalent dose lower limit; AEDU, administered equivalent dose upper limit; AED values are expressed as mg/kg bw/day.