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. 2021 Apr 1;47(6):93. doi: 10.3892/ijmm.2021.4926

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Copyright: © Xing et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Interference with MIR4435-2HG inhibits the activation of FAK-AKT-β-catenin signaling pathway in vitro and in vivo. (A) The expression of β-catenin, c-MYC and cyclin D1 in PC-3 cells transfected with shRNA-MIR4435-2HG was detected by western blot analysis. ^*P<0.05 and ^**P<0.01 vs. control group; ^#P<0.05 and ^##P<0.01 vs. shRNA-NC group. (B) The expression of β-catenin, c-MYC and cyclin D1 in tumor tissues of mice subcutaneously injected with PC-3 cells transfected with shRNA-MIR4435-2HG was detected by western blot analysis. ^***P<0.001 vs. control group.