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. 2021 Apr 1;47(6):93. doi: 10.3892/ijmm.2021.4926

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Copyright: © Xing et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Interference with ST8SIA1 inhibits the promoting effects of MIR4435-2HG on the invasion and migration of prostate cancer cells. (A) Microscope images reflecting migration of PC-3 cells transfected with pcDNA-MIR4435-2HG and shRNA-ST8SIA1 (magnification, ×100). (B) Microscope images reflecting the invasion of PC-3 cells transfected with pcDNA-MIR4435-2HG and shRNA-ST8SIA1 (magnification, ×100). (C) The migration of PC-3 cells transfected with pcDNA-MIR4435-2HG and shRNA-ST8SIA1 was detected by wound healing assay. (D) The invasion of PC-3 cells transfected with pcDNA-MIR4435-2HG and shRNA-ST8SIA1 was detected by Transwell assay. (E) The MMP2 and MMP9 in PC-3 cells transfected with pcDNA-MIR4435-2HG and shRNA-ST8SIA1 was examined by western blot analysis. ^*P<0.05, ^**P<0.01 and ^***P<0.001 vs. control group; ^###P<0.001 vs. pcDNA-NC group. ^∆P<0.05 and ^∆∆∆P<0.001 vs. pcDNA-MIR4435-2HG + shRNA-NC group.