TABLE 2.

Predictive factors for ovarian hyperstimulation syndrome in fresh autologous and embryo banking cycles from 2010 to 2015.

	Fresh autologous cycles in which embryo transfer occurred		Fresh autologous cycles and embryo-banking cycles^b,c
Predictive factor	RR (95% CI)	aRR^a (95% CI)	RR (95% CI)	aRR^a (95% CI)
Age, y
<30	10.17 (7.99–12.95)	2.27 (1.76–2.92)	17.58 (14.58–20.24)	6.47 (5.46–7.66)
30–34	7.17 (5.67–9.08)	2.02 (1.58–2.59)	11.5 (9.79–13.51)	4.97 (4.22–5.86)
35–37	4.71 (3.68–6.01)	1.79 (1.39–2.31)	6.49 (5.49–7.67)	3.43 (2.89–4.06)
38–40	2.67 (2.06–3.46)	1.49 (1.14–1.94)	3.17 (2.65–3.78)	2.12 (1.77–2.54)
≥41	Reference	Reference	Reference	Reference
Race
Non-Hispanic White	Reference	Reference	Reference	Reference
Non-Hispanic Black	1.1 (0.96–1.27)	1.27 (1.10–1.46)	1.18 (1.08–1.29)	1.37 (1.25–1.49)
Asian/Pacific Islander	0.88 (0.79–0.98)	1.01 (0.91–1.14)	0.72 (0.67–0.77)	0.86 (0.79–0.92)
Hispanic	1.08 (0.95–1.22)	1.18 (1.04–1.34)	1.06 (0.98–1.16)	1.11 (1.02–1.21)
Other	0.55 (0.21–1.48)	0.63 (0.24–1.65)	0.54 (0.28–1.04)	0.49 (0.25–0.94)
Body mass index, kg/m²
<18.5	0.94 (0.74–1.20)	0.95 (0.74–1.21)	0.99 (0.86–1.15)	0.99 (0.85–1.15)
18.5–24.9	Reference	Reference	Reference	Reference
25.0–29.9	0.83 (0.76–0.92)	0.82 (0.75–0.90)	0.92 (0.86–0.99)	0.86 (0.80–0.92)
≥30.0	0.72 (0.65–0.81)	0.66 (0.59–0.74)	0.91 (0.85–0.98)	0.70 (0.65–0.76)
Previous pregnancy
Yes	0.76 (0.70–0.82)	0.91 (0.84–0.98)	0.66 (0.63–0.70)	0.84 (0.80–0.89)
No	Reference	Reference	Reference	Reference
Current pregnancy^b
Yes	4.56 (4.11–5.06)	3.12 (2.81–3.47)	N/A	N/A
No	Reference	Reference	Reference	Reference
Ovulatory disorder
Yes	3.18 (2.94–3.44)	2.01 (1.84–2.19)	3.96 (3.76–4.16)	2.61 (2.47–2.76)
No	Reference	Reference	Reference	Reference
Uterine factor
Yes	1.18 (1.00–1.38)	1.48 (1.26–1.73)	0.95 (0.85–1.06)	1.17 (1.05–1.31)
No	Reference	Reference	Reference	Reference
Tubal factor
Yes	1.04 (0.94–1.15)	1.22 (1.10–1.36)	1.11 (1.04–1.19)	1.14 (1.07–1.23)
No	Reference	Reference	Reference	Reference
Endometriosis
Yes	1.14 (1.02–1.29)	1.21 (1.07–1.36)	1.08 (0.99–1.17)	0.94 (0.87–1.03)
No	Reference	Reference	Reference	Reference
Diminished ovarian reserve
Yes	0.16 (0.13–0.19)	0.47 (0.39–0.57)	0.12 (0.11–0.14)	0.27 (0.24–0.31)
No	Reference	Reference	Reference	Reference
Unexplained infertility
Yes	0.81 (0.73–0.91)	0.97 (0.86–1.09)	0.87 (0.81–0.94)	0.92 (0.84–1.00)
No	Reference	Reference	Reference	Reference
No. of oocytes retrieved^c
0–10	0.25 (0.22–0.29)	0.37 (0.32–0.42)	N/A	N/A
11–15	Reference	Reference	N/A	N/A
16–30	2.2 (2.01–2.42)	1.90 (1.73–2.08)	N/A	N/A
>30	5.15 (4.51–5.87)	3.85 (3.364.41)	N/A	N/A
GnRH antagonist cycle
Yes	0.74 (0.69–0.80)	0.79 (0.73–0.85)	N/A	N/A
No	Reference	Reference	Reference	Reference
Embryo-banking cycle^d
Yes	N/A	N/A	0.45 (0.42–0.49)	0.66 (0.61–0.72)
No	Reference	Reference	Reference	Reference

Note: aRR = adjusted risk ratio; RR = risk ratio.

Risk ratios were adjusted for age, race, body mass index, previous pregnancy, current pregnancy, diagnosis of ovulatory disorder, uterine factor, tubal factor, endometriosis, diminished ovarian reserve, unexplained infertility, number of oocytes retrieved, GnRH antagonist use for pituitary suppression, and embryo-banking cycle.

Includes embryo-banking cycles, fresh autologous cycles where no transfer was attempted or where no embryos were transferred, and fresh autologous cycles where embryo transfer occurred. Because pregnancy is not possible after an embryo-banking cycle, current pregnancy is not in the model that includes embryo-banking cycles.

Excludes cancelled cycles in which a retrieval was not performed.

Because of missing data, aRR of ovarian hyperstimulation syndrome was not calculated for number of oocytes retrieved or use of a GnRH antagonist in embryo-banking cycles.