TABLE 3.
Association between ovarian hyperstimulation syndrome and pregnancy outcomes among fresh autologous cycles, 2010 to 2015.
| Cycles without OHSS | Cycles with OHSS | ||||
|---|---|---|---|---|---|
| Outcome | n (%) | aRR | n (%) | RR | aRR |
| For singleton gestation | |||||
| First-trimester loss (<14 wk)a | 1,4678 (11.50) | Reference | 98 (8.58) | 0.75 (0.62–0.90) | 0.86 (0.71–1.04) |
| Second-trimester loss (14–20 wk)b | 1,362 (1.20) | Reference | 10 (0.96) | 0.80 (0.43–1.48) | 0.87 (0.47–1.61) |
| Stillbirthc | 704 (0.63) | Reference | 7 (0.68) | 1.07 (0.51–2.25) | 1.06 (0.51–2.22) |
| Birth weight <2,500gd | 1,0997 (9.45) | Reference | 139 (12.17) | 1.29 (1.10–1.51) | 1.29 (1.10–1.51) |
| Preterm deliveryd | 1,3916 (11.78) | Reference | 177 (15.30) | 1.3 (1.13–1.49) | 1.32 (1.15–1.51) |
| For multiple gestation | |||||
| First-trimester loss (<14 wk)e | 1,398 (2.59) | Reference | 16 (1.71) | 0.66 (0.41–1.08) | 0.71 (0.43–1.15) |
| Second-trimester loss (14–20 wk)f | 650 (1.23) | Reference | 20 (2.17) | 1.77 (1.14–2.74) | 1.81 (1.17– 2.81) |
| Stillbirthg | 421 (0.81) | Reference | 10 (1.11) | 1.38 (0.74–2.57) | 1.38 (0.74–2.57) |
| Birth weight <2,500gh | 2,8228 (69.33) | Reference | 515 (74.10) | 1.07 (1.02–1.12) | 1.06 (1.02–1.11) |
| Preterm deliveryh | 2,4225 (58.34) | Reference | 483 (67.84) | 1.16 (1.10–1.22) | 1.16 (1.10–1.22) |
Note: aRR = adjusted risk ratio; OHSS = ovarian hyperstimulation syndrome; RR = risk ratio.
Where number of fetal heart beats = 1. Risk ratios adjusted for age, number of prior miscarriages, body mass index, uterine-factor infertility, and race.
Where number of fetal heart beats = 1 and no first-trimester loss. Risk ratios adjusted for age, number of prior miscarriages, body mass index, uterine-factor infertility, and race.
Where number of fetal heart beats = 1 and no first- or second-trimester loss. Risk ratios adjusted for age, body mass index, uterine-factor infertility, primigravid status, and race.
For singleton pregnancies resulting in live birth. Risk ratios adjusted for age, number of previous preterm deliveries, body mass index, uterine-factor infertility, and race.
Where number of fetal heartbeats ≥2. Risk ratios adjusted for age, number of previous miscarriages, body mass index, uterine-factor infertility, and race.
Where number of fetal heartbeats ≥2 and no first-trimester loss. Risk ratios adjusted for age, number of prior miscarriages, body mass index, uterine factor infertility, and race.
Where number of fetal heartbeats ≥2 and no first- or second-trimester loss. Risk ratios adjusted for age, body mass index, uterine-factor infertility, primigravid status, and race.
For twin pregnancies resulting in live birth. Risk ratios adjusted for age, number of previous preterm deliveries, body mass index, uterine-factor infertility, and race.