TABLE 1.

Risk of Pancreatic Cancer in Hereditary Syndromes

	% of Families	Increased Risk	Age 50 y, %	Age 70 y, %
No history	—	1	0.05%	0.5
Hereditary nonpolyposis colorectal cancer	?	8	1	3.7
BRCA2 (breast-ovarian)	6–12	3.5–10	0.5–2	5
PALB2	3	?	?	?
Familial atypical multiple mole melanoma (p16)	1–3	20–34	1	10–17
Familial pancreatitis (PRSS1)	<1	50–80	2.5	25–40
Peutz-Jeghers (STK11/LKB1)	<1	132	6.6	30–60
ATM	<2	?	?	?

Data extracted from https://seer.cancer.gov/statfacts/html/pancreas.html.