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. 2021 Apr 12;9(4):E552–E561. doi: 10.1055/a-1352-2709

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The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

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Fig. 2 — Representative histological and macroscopic images in flat-type dysplasia. a Representative histological images of flat-type high-grade dysplasia (HGD) (Case #7). The histological findings for the resected specimen: HE staining indicating a flat-type HGD lesion (upper) and p53 immunohistochemistry (middle) indicating overexpression of p53. Note that CD34-positive vessels in the mucosa were increased in the HGD lesions compared to in the adjacent non-neoplastic lesions by CD34 immunohistochemistry (lower). The rectangle dysplastic (red line) and non-neoplastic (blue line) areas are magnified below. Scale bars, 500 μm. b Representative macroscopic images of resected specimens of flat-type dysplasia showing mucosal vascular densities (Case #2, #5, and #7). Red and blue dots indicate high- and low-density of intramucosal vessels, respectively. The 75 ^th percentile was used to determine high- and low-density of intramucosal vessels as described in the “Patients and methods” section. Dysplastic areas confirmed by histological assessment were lined by yellow dotted lines. Case #7 contains a sessile lesion indicated by a black dotted line.